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Should I increase or decrease my methadone during pregnancy?
Lowering the methadone dosage may affect the mother's ability to remain drug free, especially since some studies have indicated that methadone metabolism accelerates during the last trimester of pregnancy. Thus, "increasing the dose of methadone might be necessary to prevent withdrawal symptoms late in pregnancy." Alternatively, "splitting the dose of methadone into a twice-daily schedule" may help to avoid the need to increase the dosage.


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